Comparison of efficacy and safety of Amisulpride and Risperidone in treating patients with schizophrenia

Objective:To compare the efficacy and safety between Amisulpride and Risperidone in treatment of schizophrenia.Methods:140 patients with schizophrenia who met the schizophrenia criterion of Chinese classification of mental disorder were divided into two groups randomly and treated with Amisulpride and Risperidone for 8 weeks.The positive and negative scale(PANSS) and treatment emergent side effect scale(TESS) were used to evaluate the efficacy and adverse effect respectively.Results: The cure rate of Amisulpride group was 34.3% and efficacy rate was 77.1% after 8 weeks.While 32.9% and 75.7% in Risperidone group.There were no statistical different between two groups(P0.05).The incidence rate of adverse effect was 41.43% in Amisulpride group and that was 45.7% in Risperdone group,with statistical different between them(P0.05).Conclusions: Amisulpride and Risperdone are similarly effective and adverse effect in the treatment of schizophrenia.We can choice suitable drug by patients 'condition.