Clinical efficacy and safety evaluationof Nifedipine combined with Enalapril in the treatment ofelderly hypertension

Objective Evaluating the efficacy and safety of extended release Nifedipinetablets combined with Enalaprilin the treatment of elderly hypertension. Methods Categorizing 150 cases of elderly hypertension patients into A,B and C randomly,each group contains 50 patients. Patients in group A were applied with extended release Nifedipine tablets. Patientsin Group B were applied with Enalapril. Patientsin Group C were applied with extended release Nifedipine tablets and Enalapril. The efficacy,blood pressure value and adverse reactions of the patients after receiving treatment were compared. Results After received corresponding treatment for one week,the systolic pressures of patients in Group C were found to be significantly lower than patients in Groups A and B( P 0. 05). After one or two weeks' treatment,the diastolic pressure of group C was low than that of group A or group B. After four weeks of treatment,the marked improvement rate of Group C was significantly higher than Groups A and B( P 0. 05). The adverse reaction rate of the three groups registered no significant differences( P 0. 05). Conclusions The combination use of extended release Nifedipine tablets and Enalapril in the treatment of elderly hypertension could reinforce the blood pressure reduction effectively with good safety and would be worth of promoting in clinical application.