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Multi Center Clinical Study on Treatment of Bacterial Infections with Meropenem

You Liu

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Abstract

OBJECTIVE To evaluate the efficacy and safety of domestic meropenem. METHODS A randomized comparative multicenter study was conducted to compare the efficacy and safety of domestic meropenem versus imipenem/cilastatin in the treatment of 125 cases of moderate and severe lower respiratory tract infection, urinary tract infection and infection on the surface of wound of burn. RESULTS The clinical effective and bacteriological eradication rates were 89.36% and 82.26%, respectively in meropenem group and those of the control one were 89.83% and 75.00%, respectively. Adverse events were reported in 7.4% of patients in meropenem group and 11.86% in the control one, respectively. CONCLUSIONS There were no significant differences of efficacy and adverse effect between the two groups.

About this research paper

What this paper is about

OBJECTIVE To evaluate the efficacy and safety of domestic meropenem. METHODS A randomized comparative multicenter study was conducted to compare the efficacy and safety of domestic meropenem versus imipenem/cilastatin in the treatment of 125 cases of moderate and severe lower respiratory tract infection, urinary tract infection and infection on the surface of wound of burn. RESULTS The clinical effective and bacteriological eradication rates were 89.36% and 82.26%, respectively in meropenem group and those of the control one were 89.83% and 75.00%, respectively. Adverse events were reported in 7.4% of patients in meropenem group and 11.86% in the control one, respectively. CONCLUSIONS There were no significant differences of efficacy and adverse effect between the two groups.

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Available abstract

OBJECTIVE To evaluate the efficacy and safety of domestic meropenem. METHODS A randomized comparative multicenter study was conducted to compare the efficacy and safety of domestic meropenem versus imipenem/cilastatin in the treatment of 125 cases of moderate and severe lower respiratory tract infection, urinary tract infection and infection on the surface of wound of burn. RESULTS The clinical effective and bacteriological eradication rates were 89.36% and 82.26%, respectively in meropenem group and those of the control one were 89.83% and 75.00%, respectively. Adverse events were reported in 7.4% of patients in meropenem group and 11.86% in the control one, respectively. CONCLUSIONS There were no significant differences of efficacy and adverse effect between the two groups.

Key concepts: Meropenem, Medicine, Imipenem/cilastatin, Imipenem, Adverse effect, Internal medicine, Cilastatin, Clinical efficacy

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