2001•Chinese Journal of Clinkal Oncology and RehabilitationRequires access
Chromosome 10q may harbor several tumor supppressor genes in glioblastomas
Jiang Cheng
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Abstract
Objective Nine loci on chromosome 10q were examined to detect LOH in 10 cases of glioblastoma in order to locate the deletion areas probably harboring tumor suppressor genes.Methods PCR based microsatellite polymorphism analyses were performed to detect LOH on chromosome 10q.Results 90% informative cases of GBM displayed LOH on 10q.71% of informative loci showed LOH in our series,in which the most frequent LOH were observed at loci fromD10s2492 to D10s541 on 10q 23 and from D10s1723 to D10s216 on 10q 25-26 .Conclusions Loss of genetic material on chromosome 10q may play an important role in the initiation and progression of GBM.The chromosomal regions at loci from D10s2492 to D10s541 on 10q 23 and from D10s1723 to D10s216 on 10q 25-26 may harbor several tumor suppressor genes associated with GBM.