ScholarLens Back to search
2000•Chinese Journal of Clinical NeurosciencesRequires access

A Primary Study of Loss of Heterozygosity on Chromosome 10q in Glioblastoma

Jiang Cheng

Open publisher page 0 citations

Abstract

Aim:The LOH study was performed to locate the deletion areas probably harboring tumor suppressor genes and provide clues for discovering tumor suppressor genes. Methods: Nine polymorphic microsatellite markers on chromosome 10q in l0 cases of glioblastoma (GBM) were analyzed to detect LOH by PCR based technique. Results: 90% informative cases of GBM displayed LOH on 10q. The most frequent LOH were observed at loci from D10s2492 to D10s54l on 10q~(23) and from D10s1723 to D10s216 on 10q~(25-26). Conclusion: The chromosomal regions at loci from D10s2492 to D10s541 on 10q~(23) and from D10s1723 to D10s216 on 10q~(25-26) may harbor tumor suppressor genes associated with GBM.

About this research paper

What this paper is about

Aim:The LOH study was performed to locate the deletion areas probably harboring tumor suppressor genes and provide clues for discovering tumor suppressor genes. Methods: Nine polymorphic microsatellite markers on chromosome 10q in l0 cases of glioblastoma (GBM) were analyzed to detect LOH by PCR based technique. Results: 90% informative cases of GBM displayed LOH on 10q. The most frequent LOH were observed at loci from D10s2492 to D10s54l on 10q~(23) and from D10s1723 to D10s216 on 10q~(25-26). Conclusion: The chromosomal regions at loci from D10s2492 to D10s541 on 10q~(23) and from D10s1723 to D10s216 on 10q~(25-26) may harbor tumor suppressor genes associated with GBM.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Aim:The LOH study was performed to locate the deletion areas probably harboring tumor suppressor genes and provide clues for discovering tumor suppressor genes. Methods: Nine polymorphic microsatellite markers on chromosome 10q in l0 cases of glioblastoma (GBM) were analyzed to detect LOH by PCR based technique. Results: 90% informative cases of GBM displayed LOH on 10q. The most frequent LOH were observed at loci from D10s2492 to D10s54l on 10q~(23) and from D10s1723 to D10s216 on 10q~(25-26). Conclusion: The chromosomal regions at loci from D10s2492 to D10s541 on 10q~(23) and from D10s1723 to D10s216 on 10q~(25-26) may harbor tumor suppressor genes associated with GBM.

Key concepts: Loss of heterozygosity, Suppressor, Chromosome, Glioblastoma, Biology, Microsatellite, Gene, Tumor suppressor gene

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
A Primary Study of Loss of Heterozygosity on Chromosome 10q in Glioblastoma — Research Paper | ScholarLens