2007•PubMedRequires access
[To explore the clinical significance of HBV large protein (HBV-LP) in diagnosing viral replication].
Yu-hua Gong, Yun Hu, Lili Zhang, Qin Su, Ren-lian Diao, Jia-wen Miao
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Abstract
OBJECTIVE: To explore the clinical significance of HBV large protein (HBV-LP) in diagnosing viral replication, we detected the HBV-LP, HBV DNA and the hepatitis B viral markers (HBV M) in the serum of the patients infected with HBV. METHODS: HBV-LP and HBV M were analyzed by using ELISA. HBV-DNA was quantitatively detected using real-time fluorescent polymerase chain reaction. RESULTS: (1) No significant difference between the detectable rate of HBV DNA and HBV-LP was found in the same HBV M (P 0.05). (2) No significant difference between the positive rate of HBV DNA and HBV-LP was found in HBeAg negative patients. (3) The contents of serum HBV-LP was positively correlated with the number of HBV DNA copies. CONCLUSION: There was a close correlation between the positive rate of HBV-LP and HBV DNA, and HBV-LP is a reliable serological marker that can reflect the replication of HBV.