The correlation of HBV outer membrane large protein and HBV-DNA and its clinical significance

Objective To detect HBV outer membrane large protein(HBV-LP) and HBV- DNA,and to explore their correlation in judging the pathogenetic condition and HBV replication,as well as its clinical significance.Methods Serum level of HBV-DNA was quantitatively detected by u- sing real-time polymerase chain reaction,and while HBV-LP and HBV markers were measured with enzyme-linked immunosorbent assay(ELISA) in infected sera from 238 patients with hepatitis B.Re- sults There was significant difference of detection rate between HBV DNA and HBV-LP(P0.05). The expression of HBV-DNA and HBV-LP had significantly difference among various patterns of HBV serological markers(P0.05).HBV-LP expression was markedly correlated with the logarithm of HBV-DNA level(r=0.677,P0.01).Conclusion There is a prefect correlation between the copies of HBV-DNA and the level of HBV-LP,but HBV-LP expression can not still reflect the status of HBV replication.