Effect of Huoxue Huatan Decoction on Indexes of Biochemistry in Experimental Model of Nonalcoholic Fatty Liver in Rats

Objective:To observe the curative effect of Huoxue Huatan decoction on experimental model of nonalcoholic fatty liver in rats.Method: Experimental animals model of nonalcoholic fatty liver in rats were established by feed of fatty food for 6 weeks,then experimental animals were divided into 6 groups which were treated with Huoxue Huatan decoction and Rosiglitazone respectively for another 6 weeks.Biochemical indexes and liver tissue of rats were tested after treatment.Result: Huoxue Huatan decoction could reduce the level of alanine aminotransferase(ALT),which was much better than Rosiglitazone[(50.7±12.2),(41.3±9.9),(66.3±29.1),(56.9±14.2),(71.3±25.9)U·L-1,P0.05],and Huoxue Huatan decoction can also reduce the level of total cholesterol(TC) [(1.3±0.3),(1.5±0.4),(2.6±1.1) mmol·L-1,P0.01]and triglyceride(TG) [(0.3±0.2),(0.4±0.2),(0.5±0.2) mmol·L-1,P0.05],while the high dose group of Huoxue Huatan decoction could reduce glucose(Glu) obviously[(9.0±1.3)(11.4±2.0) mmol·L-1,P0.01] and improve the hemorheology indexes(P0.05),reduce the level of FFA[(1.77±0.29),(1.66±0.44),(2.04±0.27) μmol·mg-1,P0.05] and TG[(0.73±0.16),(0.81±0.22),(0.57±0.11),(1.06±0.33) mmol·mg-1,P0.05] in liver.Conclusion: Huoxue Huatan decoction can improve pathological conditions of nonalcoholic fatty liver disease(NAFLD) model by adjusting metabolism of blood liquid and improving liver function.