2008•Shanghai Journal of Traditional Chinese MedicineRequires access
Influence of"Qinggan Huatan Huoxue Decoction"on Gene Expressions of SREBP-1c in NASH Rats
Ying Li
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Abstract
Objective To observe the influence ofQinggan Huatan Huoxue Decoctionon the gene expression of SREBP-1c in nonalcoholic steatohepatitis(NASH) rats.Methods The model of NASH was induced by giving high-fat diets in Sprague-Dawley rats.Qinggan Huatan Huoxue Decoction(treatment group) andDanning Tablet(control group) were applied as intervention.Rats were sacrificed 12 weeks after modeling and the liver samples were kept,which were used to detect the levels of TG,FFA,and gene expression of SREBP-1c. Meanwhile,the fatty degeneration,the degrees of inflammation and necrosis of liver samples were evaluated under the light microscope after HE staining.Results The histopathologic changes were more significantly improved in the treatment group than in the control group;and the levels of TG,FFA and the gene expression of SREBP-1c were significantly decreased when compared to the model group(P0.05～0.01) and control group (P0.05).ConclusionQinggan Huatan Huoxue Decoctioncan inhibit the gene expression of SREBP-1c in the NASH rats,improve the metabolism of fatty acid,reduce the synthesis of TG,exert a good effect on anti-fatty degeneration and protect the hepatic cells from damage.