Effect of torasemide and furosemide on brain edema in patients with acute cerebral hemorrhage

Objective To compare the therapeutic effect of torasemide and furosemide in combination with 20%mannitol on brain edema in patients with acute cerebral hemorrhage.Methods Eighty-six patients with spontaneous cerebral hemorrhage were randomly divided into observation group(n = 42) and control group(n = 44).The patients underwent dehydration therapy with a same dose of torasemide and furosemide in combination with 20%mannitol for 14 d and head CT on days 1,3,7,and 14 with the volume of intracranial hematoma and cerebral edema calculated. General disturbance coefficient of the two groups was monitored with a non-invasive cerebral edema dynamic monitor at different time points.Level of venous plasma neuropeptide Y was measured in the patients.Incidence of adverse reactions was compared between the two groups.Results The cerebral edema volume,general disturbance coefficient and plasma neuropeptide Y level were significantly lower,and the 24 h urine volume was significantly higher while the amount of 24 h 20%mannitol was significantly lower in observation group than in control group on days 3,7,and 14(3688.6±269.5 ml vs 3072.8±210.4 ml,360.5±21.3 ml vs 440.2±26.3 ml,P0.05).Conclusion The effect of torasemide is better than that of furosemide on cerebral edema in patients with acute intracerebral hemorrhage with a definite therapeutic effect and fewer adverse reactions.