Influence of mannitaol on brain edema after cerebral hemorrhage

Objective To investigate the influence of mannitol on brain edema after cerebral hemorrhage.Methods The data of 51 patients with cerebral hemorrhage were retrospectively analyzed. 51 patients were randomly divided into two groups, group A (n=35) was treated with mannitol within 24 hours ,and group B (n=16) was treated with mannitol after 24 hours. Cranial CT was performed in 48 hours and 2 weeks. The influence of using mannitol within 24 hours after the onset on brain edema was analyzed.Results 5(14.3%) patients in group A had exacerbation on brain edema in 48 hours and 21 (60.0%) patients in 2 weeks, however, 1(6.3%) patients in group B had exacerbation of brain edema in 48 hours and 3(18.8%) patients in 2 weeks. There was no significant difference in cranial CT in 48 hours between the two groups (P0.05),there was a significant difference in cranial CT after two weeks between two groups (P0.01).There was a significant difference in the therapeutic effect after two weeks between two groups (P0.05).Conclusion The improper application of mannitol within 24 hours after the onset in patients with cerebral hemorrhage may increase the incidence of exacerbation of brain edema and may exacerbate patient's condition. For patients with cerebral hemorrhage within 24 hours after the onset, mannitol should be used prudently in order to prevent the disadvantage.