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2006•Unpublished venueRequires access

A comparative study of olanzapine versus clozapine in the treatment of treatment-resistant schizophrenia

LI Cui-r

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Abstract

Objective To evaluate the efficacy and safety of olanzapine in the treatment of treatment-resistant schizophrenia.Methods A total of 64 patients with treatment-resistant schizophrenia were randomly assigned to olanzapine group and clozapine group for 8 weeks of treatment. The efficacy and side effects were measured with Positive and Negative symptom Scale (PANSS) and Treatment Emergent Symptom Scale (TESS). Results The reducing rates of PANSS total score in olanzapine group and clozapine group were 39.3% and 36.6%respectively and the effective rates were 72.8%and 59.4%respectively.No severe side effect was found in olanzapine group. Conclusion Olanzapine and clozapine are both effective for treating treatment-resistant schizophrenia.Olanzapine has fewer side effects and good compliance.

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What this paper is about

Objective To evaluate the efficacy and safety of olanzapine in the treatment of treatment-resistant schizophrenia.Methods A total of 64 patients with treatment-resistant schizophrenia were randomly assigned to olanzapine group and clozapine group for 8 weeks of treatment. The efficacy and side effects were measured with Positive and Negative symptom Scale (PANSS) and Treatment Emergent Symptom Scale (TESS). Results The reducing rates of PANSS total score in olanzapine group and clozapine group were 39.3% and 36.6%respectively and the effective rates were 72.8%and 59.4%respectively.No severe side effect was found in olanzapine group. Conclusion Olanzapine and clozapine are both effective for treating treatment-resistant schizophrenia.Olanzapine has fewer side effects and good compliance.

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Available abstract

Objective To evaluate the efficacy and safety of olanzapine in the treatment of treatment-resistant schizophrenia.Methods A total of 64 patients with treatment-resistant schizophrenia were randomly assigned to olanzapine group and clozapine group for 8 weeks of treatment. The efficacy and side effects were measured with Positive and Negative symptom Scale (PANSS) and Treatment Emergent Symptom Scale (TESS). Results The reducing rates of PANSS total score in olanzapine group and clozapine group were 39.3% and 36.6%respectively and the effective rates were 72.8%and 59.4%respectively.No severe side effect was found in olanzapine group. Conclusion Olanzapine and clozapine are both effective for treating treatment-resistant schizophrenia.Olanzapine has fewer side effects and good compliance.

Key concepts: Olanzapine, Clozapine, Schizophrenia (object-oriented programming), Negative symptom, Medicine, Internal medicine, Psychology, Psychiatry

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