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2007•Medical Journal of Chinese People's HealthRequires access

A comparative study of Olanzapine versus Clozapine in the treatment of treatment-resistant schizophrenia

Xianli Meng

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Abstract

Objective:To evaluate the efficacy and safety of Olanzapine in the treatment of treatment-resistant schizophrenia.Methods:A total of 76 patients with treatment-resistant schizophrenia were randomly assigned to the Olanzapine group and the Clozapine group for 12 weeks of treatment.The efficacy and side effects were measured with Positive and Negative symptom Scale(PANSS) and Treatment Emergent Symptom Scale(TESS).Results: The reducing rates of PANSS total score in the Olanzapine group and the Clozapine group were 38.05% and 36.58% respectively and the effective rates were 68.42% and 60.53% respectively.No severe side effect was found in the Olanzapine group.Conclusions: Olanzapine and Clozapine are both effective for treating treatment-resistant schizophrenia.Olanzapine has fewer side effects and good compliance.

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What this paper is about

Objective:To evaluate the efficacy and safety of Olanzapine in the treatment of treatment-resistant schizophrenia.Methods:A total of 76 patients with treatment-resistant schizophrenia were randomly assigned to the Olanzapine group and the Clozapine group for 12 weeks of treatment.The efficacy and side effects were measured with Positive and Negative symptom Scale(PANSS) and Treatment Emergent Symptom Scale(TESS).Results: The reducing rates of PANSS total score in the Olanzapine group and the Clozapine group were 38.05% and 36.58% respectively and the effective rates were 68.42% and 60.53% respectively.No severe side effect was found in the Olanzapine group.Conclusions: Olanzapine and Clozapine are both effective for treating treatment-resistant schizophrenia.Olanzapine has fewer side effects and good compliance.

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Available abstract

Objective:To evaluate the efficacy and safety of Olanzapine in the treatment of treatment-resistant schizophrenia.Methods:A total of 76 patients with treatment-resistant schizophrenia were randomly assigned to the Olanzapine group and the Clozapine group for 12 weeks of treatment.The efficacy and side effects were measured with Positive and Negative symptom Scale(PANSS) and Treatment Emergent Symptom Scale(TESS).Results: The reducing rates of PANSS total score in the Olanzapine group and the Clozapine group were 38.05% and 36.58% respectively and the effective rates were 68.42% and 60.53% respectively.No severe side effect was found in the Olanzapine group.Conclusions: Olanzapine and Clozapine are both effective for treating treatment-resistant schizophrenia.Olanzapine has fewer side effects and good compliance.

Key concepts: Olanzapine, Clozapine, Schizophrenia (object-oriented programming), Negative symptom, Internal medicine, Medicine, Side effect (computer science), Psychology

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