Effectiveness of olanzapine in treatment of schizophrenia

Objective:To explore the efficacy and safety of olanzapine in the treatment of schizophrenia. Method:123 cases with schizophrenia were randomly divided into olanzapine group(n=61) or clozapine group(n=62).Positive and negative symptoms scale (PANSS) and treatment emergant symptom scale (TESS) were used to measure the efficacy and safety before treatment and at the end of 1st,2nd,4th,6th and 8th week treatment respectively. Results:There were no significant differences in effectiveness between two groups. However, significant differences were found between two groups in the reduction rates of scales about cognitive factors and negative symptoms. Conclusion:The study suggests that olanzapine is a safe and effective agent in the treatment of schizophrenia.