The effect of olanzapine combined with clozapine in the treatment of refractory schizophrenia

Objective:To investigate the efficacy and adverse reactions of olanzapine combined with clozapine in the treatment of refractory schizophrenia. Method:The 50 patients of refractory schizophrenia were randomly divided into combined drug group and single-use drug group,25 cases each.Combination group were given a small dose of olanzapine combined with clozapine,single group were given olanzapine,treatment lasted 12 weeks.Positive and negative syndrome scale(PANSS) and treatment emergent symptom scale(TESS) were used to evaluate the efficacy and adverse drug reactions,before treatment and 4,8,12 weeks after starting treatment were assessed respectively. Results:The scores of total PANSS and positive and negative factor scores were decreased in both groups(P0.01 or P0.05) ,but they decreased more quickly in the combined group(P0.05) .Adverse reactions difference between the two groups was not significant(P0.05) . Conclusion:Olanzapine combined with clozapine treatment of refractory schizophrenia,can significantly improve the positive and negative symptoms,better efficacy,fewer side effects and better compliance.