A sfudy of angiotensin converting enzyme gene polymorphism in essential Hypertension

Obstractive:To investigate angiotensin converting enzyme(ACE) gene polymorphism in essential hypertension(EH).Methods:Polymerase chain reaction Restriction fragment length polymorphism(PCR RFLP) were used to detect the gene type frequency and polymorphism of ACE in 152 patients of EH and 111 normal controls.Results:The frequency of D allele of ACE gene is significantly higher in EH than in normal controls,and this difference only exists in males.Conclusion:There is significant difference in the distribution of ACE genotypes between hypertensives and controls in males.