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Relationship between Angiotensin Converting Enzyme Gene Polymorphism and Serum Angiotensin Converting Enzyme Activity

Luo Zheng-l

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Abstract

To study the relationship between angiotensin converting enzyme(ACE) gene polymorphism and angiotensin converting enzyme activity,the polymerase chain reaction(PCR) was used to detect an insertion/deletion(I/D) polymorphism of ACE gene in its sixteenth intron.The genotype,enzyme coupling spectrophotometry were used to measure serum ACE activity among the three genotypes.Results showed that the Serum ACE activities were (337 6±92 0),(292 7±76 5 )and(243 5±58 9)u/L for genotypes DD,ID and ⅠⅠ respectively.The findings indicate that the ACE gene polymorphism closely associated with serum ACE activity.

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What this paper is about

To study the relationship between angiotensin converting enzyme(ACE) gene polymorphism and angiotensin converting enzyme activity,the polymerase chain reaction(PCR) was used to detect an insertion/deletion(I/D) polymorphism of ACE gene in its sixteenth intron.The genotype,enzyme coupling spectrophotometry were used to measure serum ACE activity among the three genotypes.Results showed that the Serum ACE activities were (337 6±92 0),(292 7±76 5 )and(243 5±58 9)u/L for genotypes DD,ID and ⅠⅠ respectively.The findings indicate that the ACE gene polymorphism closely associated with serum ACE activity.

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Available abstract

To study the relationship between angiotensin converting enzyme(ACE) gene polymorphism and angiotensin converting enzyme activity,the polymerase chain reaction(PCR) was used to detect an insertion/deletion(I/D) polymorphism of ACE gene in its sixteenth intron.The genotype,enzyme coupling spectrophotometry were used to measure serum ACE activity among the three genotypes.Results showed that the Serum ACE activities were (337 6±92 0),(292 7±76 5 )and(243 5±58 9)u/L for genotypes DD,ID and ⅠⅠ respectively.The findings indicate that the ACE gene polymorphism closely associated with serum ACE activity.

Key concepts: Angiotensin-converting enzyme, Genotype, Gene polymorphism, Enzyme, Polymerase chain reaction, Polymorphism (computer science), Gene, Enzyme assay

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