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2002•Chinese Journal of HypertensionRequires access

Lack of Association of the Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme Gene with Essential Hypertension

Zhi Wang

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Abstract

Objective To investigate the potential association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism with essential hypertension. Methods 941 subjects from the employees of Kailuan Coal Mines were randomly enrolled. A 287 bp I/D polymorphism in intron 16 of the ACE gene was examined by polymerase chain reaction. Results Polymorphism was characterized by three genotypes: homozygous alleles DD, II, and heterozygous alleles ID. The prevalence rates of the essential hypertension in the three groups were not different between before and after 10 years ( P 0 05). Conclusion There was no significant interaction between the I/D polymorphism of ACE gene and essential hypertension.

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Objective To investigate the potential association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism with essential hypertension. Methods 941 subjects from the employees of Kailuan Coal Mines were randomly enrolled. A 287 bp I/D polymorphism in intron 16 of the ACE gene was examined by polymerase chain reaction. Results Polymorphism was characterized by three genotypes: homozygous alleles DD, II, and heterozygous alleles ID. The prevalence rates of the essential hypertension in the three groups were not different between before and after 10 years ( P 0 05). Conclusion There was no significant interaction between the I/D polymorphism of ACE gene and essential hypertension.

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Available abstract

Objective To investigate the potential association of the angiotensin converting enzyme gene (ACE) insertion/deletion (I/D) polymorphism with essential hypertension. Methods 941 subjects from the employees of Kailuan Coal Mines were randomly enrolled. A 287 bp I/D polymorphism in intron 16 of the ACE gene was examined by polymerase chain reaction. Results Polymorphism was characterized by three genotypes: homozygous alleles DD, II, and heterozygous alleles ID. The prevalence rates of the essential hypertension in the three groups were not different between before and after 10 years ( P 0 05). Conclusion There was no significant interaction between the I/D polymorphism of ACE gene and essential hypertension.

Key concepts: Essential hypertension, Allele, Genotype, Angiotensin-converting enzyme, Gene, Polymorphism (computer science), Polymerase chain reaction, Genetics

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Lack of Association of the Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme Gene with Essential Hypertension — Research Paper | ScholarLens