2012•Wuhan Daxue xuebao. Yixue banRequires access

Effects of Trimetazidine on Cardiac Fibrosis in Rats with Experimental Diabetic Cardiomyopathy

Liqun He

Abstract

Objective: To investigate the effects of trimetazidine on cardiac fibrosis in rats with experimental diabetic cardiomyopathy(DC).Methods: DC was induced in male Sprague-Dawley rats by STZ intraperitoneally injection.Rats randomly received saline(n=10) or trimetazidine(7.5 mg per kg weight per day,n=10) for 8 weeks by gavage.Another 10 healthy rats were served as controls.Myocardial hydroxyproline content as well as interstitial collagen volume fraction(ICVF) were determined.Results: Myocardial hydroxyproline and ICVF were more significantly reduced in trimetazidine treated DC rats as compared to saline treated DC rats(all P0.05).Conclusion: Trimetazidine could decrease the concentration of myocardial hydroxyproline and ICVF in diabetic cardiomyopathy rats.

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Key concepts: Trimetazidine, Hydroxyproline, Diabetic cardiomyopathy, Saline, Medicine, Cardiomyopathy, Internal medicine, Fibrosis