Effect of trimetazidine on the production of collagen in acute myocardial infarction rat

Objective To study the effect of trimetazidine on the production of collagen in acute myocardial infarction(AMI) rat.Methods 48 rats surviving left anterior descending coronary artery ligation were randomly divided into AMI model,metoprolol(2 mg·kg-1·d-1) and trimetazidine(10 mg·kg-1·d-1) with additional eight other rats being sham.Eight weeks later,the expressions of collagen types Ⅰ(collagen I) were measured by RT-PCR both in infarct zone(IZ) and non-infarct zone(NIZ).Results Compared with those of sham rats,the expressions of collagen Ⅰ of model rats and the other two admission groups were evidently increased(P﹤0.05).Compared with those of model rats,the expressions were down-regulated in metoprolol rats and trimetazidine rats.There were no significant differences between metoprolol and trimetazidine rats(P﹥0.05).The expressions collagen Ⅰ in NIZ were as follow:compared with those of sham rats,the expressions of model rats and the other two admission groups were evidently increased(P﹤0.05).Compared with those of model rats,the expressions were down-regulated in metoprolol and trimetazidine rats,but having no significant differences between the two admission groups(P﹥0.05).Conclusions Trimetazidine could significantly inhibit the production of collage in both IZ and NIZ.Trimetazidine could effectively delay the course of myocardial fibrosis.