Effect of Ningchang Decoction on Anti-Oxidative Ability of Irritable Bowel Syndrome Rats

Objective To investigate the regulation of Ningchang Decoction on free radical of stressed irritable bowel syndrome (IBS) rats. Methods The stressed IBS model rats were made by chronic bandaged-stress and inserting the end. The rats were randomly divided into six groups: normal control group, model control group, positive control group, high dosage of Ningchang Decoction group, middle dosage of Ningchang Decoction group, low dosage of Ningchang Decoction group. Different treatment were given to each group by ig administration for 4 weeks. The contents of SOD, MDA and T-AOC in serum of stressed IBS rats were determined and the regulation of Ningchang Decoction on them were observed. Results Stress increased the content of MDA in serum and decreased the contents of SOD and T-AOC in serum (P 0.05～0.01). While Ningchang Decoction could decrease the content of MDA in serum and strengthen the activity of SOD and T-AOC of stressed IBS rats (P0.05～0.01). Conclusion Ningchang Decoction could increase the antioxidation capacity of stressed IBS rats.