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2003•Chinese Journal of Hospital PharmacyRequires access

Study on supercritical fluid extraction of evodiamine and rutaecarpine in Evodia rutacearpa dahurica

Jian Li

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Abstract

OBJECTIVE To study the extraction technology of evodiamine and rutaecarpine in Fructus e vodiae by supercritical fluid, extraction and the determination of the content of evodiamine and rutaecarpine by HPLC.METHODS Waters-C 18 column was used with a mobile phase of acetonitrile water(43∶57).The flow rate was 1.0 mL·min -1 .The detection wavelength was set at 290 nm.The column temperature was 40℃.RESULTS The standard curves of evodiamine and rutaecarpine were linear in the ranges fro m 0.024 ～ 1.120 μg(r= 0.9994 )and 0.026 ～ 1.130 μg(r = 0.9995 ).The average recoveries were 101.7% with RSD= 1.79% and 102.7% with RSD= 1.58% .CONCLUSIONS The supercritical fluid extraction is rapid, and the HPLC is accurate and reprod ucible.

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OBJECTIVE To study the extraction technology of evodiamine and rutaecarpine in Fructus e vodiae by supercritical fluid, extraction and the determination of the content of evodiamine and rutaecarpine by HPLC.METHODS Waters-C 18 column was used with a mobile phase of acetonitrile water(43∶57).The flow rate was 1.0 mL·min -1 .The detection wavelength was set at 290 nm.The column temperature was 40℃.RESULTS The standard curves of evodiamine and rutaecarpine were linear in the ranges fro m 0.024 ～ 1.120 μg(r= 0.9994 )and 0.026 ～ 1.130 μg(r = 0.9995 ).The average recoveries were 101.7% with RSD= 1.79% and 102.7% with RSD= 1.58% .CONCLUSIONS The supercritical fluid extraction is rapid, and the HPLC is accurate and reprod ucible.

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Available abstract

OBJECTIVE To study the extraction technology of evodiamine and rutaecarpine in Fructus e vodiae by supercritical fluid, extraction and the determination of the content of evodiamine and rutaecarpine by HPLC.METHODS Waters-C 18 column was used with a mobile phase of acetonitrile water(43∶57).The flow rate was 1.0 mL·min -1 .The detection wavelength was set at 290 nm.The column temperature was 40℃.RESULTS The standard curves of evodiamine and rutaecarpine were linear in the ranges fro m 0.024 ～ 1.120 μg(r= 0.9994 )and 0.026 ～ 1.130 μg(r = 0.9995 ).The average recoveries were 101.7% with RSD= 1.79% and 102.7% with RSD= 1.58% .CONCLUSIONS The supercritical fluid extraction is rapid, and the HPLC is accurate and reprod ucible.

Key concepts: Evodiamine, Rutaecarpine, Chromatography, Extraction (chemistry), Supercritical fluid, Chemistry, High-performance liquid chromatography, Supercritical fluid extraction

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Study on supercritical fluid extraction of evodiamine and rutaecarpine in Evodia rutacearpa dahurica — Research Paper | ScholarLens