2013•Huanqiu zhongyiyaoRequires access
Clinical study on the efficacy of Yiqi Yangyin Huoxue Decoction for treating early diabetic nephropathy due to deficiency of Qi-Yin and blood stasis
Deng Xiao-mi
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Abstract
Objective To observe the clinical efficacy of Yiqi Yangyin Huoxue Decoction for treating the early diabetic nephropathy(DN).Methods 120 patients were randomly but equally divided into treatment group and control group,each with 60 cases at the beginning(56 cases in treatment group and 57cases in control group were finally included for further research),cases in both groups took insulin or oral hypoglycemic agents conventionally to control blood sugar,and cases in control group took benazepril hydrochl oride tablets(BHT),on the basis of the control group,cases in treatment group took Yiqi Yangyin Huoxue Decoction.Fasting plasma glucose(FPG),2-hour postprandial blood glucose,glycosylated hemoglobin,urinary albumin excretion rate(UAER),serum total cholesterol(TC),triglyceride(TG) and hemorheology changes were observed before and after the treatment.Results Clinical efficacy of treatment group was better than control group(P0.05);FPG were significantly decreased in 2 groups(P 0.01),but difference between the two groups showed no significance(P 0.05);UAER was significantly decreased in 2 groups(P0.01),but it decreased more significantly in treatment group than control group(P 0.05);TC and TG were significantly decreased in treatment group(P0.01),while TC and TG were not significantly decreased in control group(P 0.05);TC and TG showed significant differences between treatment group and control group after treatment(P0.01);hemorheological parameters significantly decreased in two groups after treatment(P0.01),but improvements of whole blood viscosity low shear and high shear,erythrocyte aggregation index were significantly better than control group(P 0.01).Conclusion The conventional treatment with Yiqi Yangyin Huoxue Decoction can improve hemorheology,renal microcirculation,and reduce the discharge of urine protein,and protect renal function in early diabetic nephropathy patients.