Effect of amlodipine combined with perindopril in patients with hypertension and microalbuminuria

Objective To examine the effects of amlodipine (Amlo) combined with perindopril (peri) used in patients with hypertension and microalbuminuria.Methods One hundred and thirty-six cases in patients with hypertension and microalbuminuria were divided randomly into two groups:group A:amlodipine 5 mg/d+perindopril 4 mg/d,n=68;group B:amlodipine 5 mg/d+12.5 mg/d,n=68.Treatment lasted for 26 weeks, parameter of blood pressurel (BP),24 h urinary albumin urine protein,blood urea nitrogen, serum creatinine,were measured before and after treatment. Results After treatment 6.5 months, both of two groups reduced blood pressure and proteinuria efficiently.In contrast, the reduction Scr and BUN were reduced more significantly in group A than in group B (P0.01).Conclusion The therapy of amlodipine combination contrast,the reduction in proteinuria can reduce in proteinuria is greater with perindopril in treating hypertentsive nephropathy with proteinuria can reduce blood pressure markly,produce a better ati-proteinuria effect,and have a better protection of renal function.