2011•Zhonghua zhongyiyao xuekanRequires access
The Impact of Rhubarb Downbearing the Turbid Granules on 5/6 Nephrectomy Rat Serum and Antral Tissue Gastrin,Plasma Motilin
XU Jin-xiu
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Abstract
Objective: To study 5 / 6 nephrectomy rat serum GAS,GAS and gastric tissue changes in plasma levels of MTL and Rhubarb Downbearing the turbid Granules interference.Methods: Wiatar male rats 5 / 6 nephrectomy rat model of CRF method of reproduction.Randomly assigned to high-dose treatment group,low-dose treatment group [all ig Rhubarb Downbearing the turbid Granules 1.0g/(kg·d),3.0g/(kg·d)] control group [ig Niaoduqing particles 2.0g/(kg·d)],a separate model group,sham operation group(ig water each),compare observed after 12 weeks of surgery,rats in each group animal mortality;24h urinary protein;T,A,Hb;serum Cr,BUN;serum GAS,gastric tissue homogenate GAS,plasma MTL.Results: After treatment,protein control group was significantly lower than model group(P0.01),large and small dose group Cr levels significantly lower than model group(P0.05,P0.01) and the control group(P0.01);treatment After the sham group GAS with large doses of serum levels were significantly lower than model group (P0.01),sham group and the treatment group GAS gastric tissue levels were significantly lower than model group(P0.01),the sham group,low-dose group and control group MTL plasma levels were significantly lower than model group(P0.05,P0.01),while the low dose group decreased significantly(P0.05).Conclusion: Rhubarb Downbearing the turbid Granules to improve high-GAS hyperlipidemia,lower levels of gastric tissue GAS,improved high-MTL hyperlipidemia;with lower creatinine,urea nitrogen,improving azotemia,protect renal function.