Effect of Senqi Xiaobi Granules on Serum Levels of GH,EGF and GAS in Rats with Chronic Atrophic Gastritis

Objective: To evaluate the effect of Senqi Xiaobi(SQ) granules on serum levels of growth hormone(GH),epidermal growth factor(EGF) and gastrin(GAS) in rats with chronic atrophic gastritis(CAG).Method: CAG model was established by N-methyl-N'-nitro-N-nitrosoguanidine(MNNG) and other comprehensive factors for 14 weeks.Then the model rats were divided into 6 groups randomly,which were ig administered with saline,Moluodan,folic acid,SQ granules 2,4,8 g.kg-1,respectively,taking normal Wistar rats as control group at the beginning of modeling.Body weight of rats was observed for 22 weeks.In 22nd week,the pathological changes of gastric mucosa were observed,serum levels of GH,EGF GAS were measured by radioimmunoassay.Result: in 22 nd week,in the model group,there were typical CAG pathological morphological changes on the gastric mucosa,Compared with model group,there were improvements on pathological changes at different degrees in the SQ Granules-treated groups;serum levels of GH in the SQ Granules 8 g.kg-1 group were significantly higher than that in the model group [(5.42 ± 0.68),(5.02 ± 0.71 μg.L-1,P 0.05) ];serum levels of EGF in the SQ granules 4,2 g.kg-1 group were significantly higher than that in the model group [(0.88 ±0.22),(0.86 ± 0.18),(0.72 ± 0.17) μg.L-1,P 0.01) ];serum levels of GAS in the SQ granules 4 g.kg-1 group and SQ granules 2 g.kg-1 group were significantly lower than that in the model group [(68.07 ±11.38),(62.42 ±10.19),(74.85 ±7.06) ng.L-1,P 0.05 or P 0.01) ].Conclusion: SQ granules improve mucosal atrophy possibly by increasing serum levels of GH,EGF and reducing serum levels of GAS in rats with chronic atrophic gastritis.