Effects of weitongxiaopi decoction on gastrin and somatostatin in rats with functional dyspepsia of liver-depression and spleen-deficiency type

Objective To explore the influence of weitongxiaopi decoction(WTXP)on gastrin(GAS)and somatostatin(SS)in serum,gastric and duodenal of rats with functional dyspepsia(FD)of liver-depression and spleen-deficiency type.Methods 40 Wistar rats were randomly divided into control,model,WTXP and cisapride(CP)groups.Except for control group,a rat model of functional dyspepsia was established by the improved tail clamp method.The FD rats were given WTXP or cisapride(CP)for 3 weeks.After treatment,the GAS serum in gastric and duodenal were examined by enzyme-linked immunosorbent assay(ELISA)and immuno-histochemical methods respectively.Results Compared with control group,the GAS content in model group was significantly lower(P0.05).After treatment,compared with model group,the GAS content of WTXP group and CP group were significantly higher(P0.05),WTXP group was significantly higher than CP group(P0.05);each treatment group was lower than control group(P0.05).Compared with control group,the SS content of model group was significantly higher(P0.05).After treatment,SS content of WTXP group and CP group were significantly lower than that of model group(P0.05);WTXP group was significantly lower than CP group;each treatment group was higher than control group(P0.05).Conclusion FD can cause the changes of the GAS and SS contents in rats.WTXP can increase the contents of GAS in serum,gastric and duodenal and decrease the content of SS in FD rats.