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2009•The Journal of Clinical PsychiatryRequires access

A controlled study between olanzapine and clozapine in the treatment of schizophrenia

Qiu Kai-fen

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Abstract

Objective:To study the influence of domestic olanzapine on clinical efficacy and quality of life. Method:64 patients with schizophrenia were randomly divided into olanzapine group and clozapine group for 8 weeks.The efficacy and adverse effects were evaluated with positive and negative syndrome scale(PANSS)and treatment emergent symptoms scale(TESS).The quality of life of patients with schizophrenia was accessed by General Quality of Life Inventory(GQOLI-74). Results:There was no significant difference in clinical efficacy between the two groups.Patients in olanzapine group had more improvement in areas of life quality compared with patients in clozapine group. Conclusion: Domestic olanzapine have similar clinical efficacy as clozapine in the treatment of schizophrenia,with more improvement in quality of life compared to clozapine.

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What this paper is about

Objective:To study the influence of domestic olanzapine on clinical efficacy and quality of life. Method:64 patients with schizophrenia were randomly divided into olanzapine group and clozapine group for 8 weeks.The efficacy and adverse effects were evaluated with positive and negative syndrome scale(PANSS)and treatment emergent symptoms scale(TESS).The quality of life of patients with schizophrenia was accessed by General Quality of Life Inventory(GQOLI-74). Results:There was no significant difference in clinical efficacy between the two groups.Patients in olanzapine group had more improvement in areas of life quality compared with patients in clozapine group. Conclusion: Domestic olanzapine have similar clinical efficacy as clozapine in the treatment of schizophrenia,with more improvement in quality of life compared to clozapine.

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Available abstract

Objective:To study the influence of domestic olanzapine on clinical efficacy and quality of life. Method:64 patients with schizophrenia were randomly divided into olanzapine group and clozapine group for 8 weeks.The efficacy and adverse effects were evaluated with positive and negative syndrome scale(PANSS)and treatment emergent symptoms scale(TESS).The quality of life of patients with schizophrenia was accessed by General Quality of Life Inventory(GQOLI-74). Results:There was no significant difference in clinical efficacy between the two groups.Patients in olanzapine group had more improvement in areas of life quality compared with patients in clozapine group. Conclusion: Domestic olanzapine have similar clinical efficacy as clozapine in the treatment of schizophrenia,with more improvement in quality of life compared to clozapine.

Key concepts: Olanzapine, Clozapine, Schizophrenia (object-oriented programming), Positive and Negative Syndrome Scale, Quality of life (healthcare), Clinical efficacy, Psychology, Adverse effect

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