The expression and their correlation of P53,Ki-67 in papillary thyroid carcinoma and follicular thyroid carcinoma

Objective To investigate the expression of P53,Ki-67 and their relationship in papillary thyroid carcinoma and follicular thyroid carcinoma.Methods Immunohistochemical method(SP) was used to detect the expression of P53 and Ki-67 in 49 cases of thyroid carcinoma including 39 cases of papillary thyroid carcinoma and 10 cases of follicular thyroid carcinoma,as well as 30 cases of thyroid adenoma.Results The positive expression rates of P53,Ki-67 were 83.6% and 69.38% respectively in thyroid carcinoma,which were significantly higher than those in thyroid adenoma.The positive expression rate of P53 was positively correlated with that of Ki-67 in thyroid carcinoma(P0.05).The expressions of P53,Ki-67 were not correlated with gender,age,tumor size and nodule number(P0.05).The positive expression rates of P53,Ki-67 were significantly different between papillary thyroid carcinoma and follicular thyroid carcinoma(P0.05).The Ki-67 proliferation index in papillary thyroid carcinoma was higher than that of follicular thyroid carcinoma.Conclusion The expression of P53 is positively correlated with that of Ki-67 in thyroid carcinoma.The Ki-67 proliferation index is different between papillary thyroid carcinoma and follicular thyroid carcinoma.