Expressions and clinical significance of Ki-67 of and P-GP170 in thyroid papillary carcinoma

Objective:To investigate the expressions and clinical significance of anti nuclear antigen Ki 67 and P GP170 (P glyco protein, P GP170) in thyroid papillary carcinoma and thyroid adenoma in order to explore the significance of these two proteins in diagnosis and treatment of thyroid tumors.Methods:SP immunohistochemical technique was applied to detection of the two antigens mentioned above in 90 cases of thyroid papillary carcinoma and 20 cases of thyroid adenoma.Statistical analysis was conducted between them.Results:The average PI (proliferation index, PI) of Ki 67 was significantly higher in thyroid papillary carcinoma than that in thyroid adenoma (77 78% vs 50.00% and 44 00±39 34 vs 16 80±17 20 respectively, P 0 05).The expression of Ki 67 was notably correlated with the expression of P GP170 ( r=0 65, P 0.01) in thyroid papillary carcinoma.Conclusions:A elevated PI was found in thyroid papillary carcinoma,indicating a high expression of Ki 67 and a stronger drug resistance.Detection of Ki 67 was helpful to the diagnosis of thyroid papillary carcinoma.PI was positively correlated with drug resistance.Detection of P GP170 was significant in guidance of chemotherapy in clinical practice.