2014•Chinese Journal of Laboratory DiagnosisRequires access
EExpression of KAI1/CD82 in Thyroid Carcinoma and its Clinical Significance
Tian Zhong-chen
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Abstract
Objective To study the expression of KAI1/CD82 in Thyroid Carcinoma and its Clinical Significance. Methods Normal thyroid tissues from twelve people and thyroid cancer tissues obtained from 35 inpatients were detect the expression of KAI1/CD82 by immunohistochemistry SP method and RT-PCR method.Results ①SP method:The positive rates of normal thyroid tissues,papillary thyroid carcinoma,follicular thyroid carcinoma,medulla thyroid carcinoma were 100%,80%,69.2%,16.7%,the KAI1/CD82positive rate increased correlated with the higher histological grade of thyroid carcinoma,but insignificant(P0.05),follicular thyroid carcinoma,medulla thyroid carcinoma were significantly lower than that in normal thyroid tissues(P0.05)②RT-PCR method:The relative contents of KAI1/ CD82in normal thyroid tissues,papillary thyroid carcinoma,follicular thyroid carcinoma,medulla thyroid carcinoma were 91.124±12.292,85.406±12.992,70.1±10.880,30.682±13.270,the relative contents of KAI1/CD82 in papillary thyroid carcinoma were lower than that in normal thyroid,but insignificant(P0.05),follicular thyroid carcinoma,medulla thyroid carcinoma were significantly lower than that in normal thyroid tissues(P0.05).Conclusion The expression of KAI1/CD82in Thyroid Carcinoma have some guiding role and significance for diagnosis and treatment, may become important index to speculate prognosis of patients.