Application of 64 multislice spiral CT cerebral perfusion imaging and CT angiography in patients with hyperacute stroke

Objective To evaluate the application of 64 multislice spiral cerebral perfusion imaging (CTP) and angiography(CTA) in patients with hyperacute stroke. Methods Conventional cerebral plain CT, CTP and CTA were performed in 30 patients with hyperacute ischemic stroke within 6 hours of onset of symptom . All cases were reexamined by cerebral plain after 2 to 14 days. Dynamic CTP images were processed with the CT Perfusion software package on workstation. Quantitative analysis of cerebral perfusion parameters were performed on CTP images. angiography was reconstructed to show carotid and intracerebral artery. Results Conventional plain of the 30 cases found no abnormality in 20 cases and early infarction signs in 10 cases. However,abnormal perfusion changes corresponding to clinical symptoms were found in all 30 cases, including decrease in cerebral blood flow(CBF) and cerebral blood volume (CBV), delayed time to peak (TTP) . There were significant differences of CBF, CBV and TTP between infarction side and contralateral side (P 0.01). CTA demonstrated stenosis or occlusion of middle cerebral artery and internal carotid artery in 30 cases. Conclusion CTP can early show the ischemic extent and penumbra and CTA can show the stenosis or occlusion of artery in patients with hyperacute stroke.