The application of 64 multislice spiral CT cerebral perfusion imaging and CT angiography in patients with TIA

Objective To evaluate the application of 64 multislice spiral CT cerebral perfusion imaging(CTP) and CT angiography(CTA)in patients with transient ischemie attacks(TIA).Methods Conventional cerebral plain CT,CTP and CTA were performed on 36 patients with TIA.After regular plain CT examination,dynamic CTP was performed while 40ml of non-ionic contrast material were bolus injected through antecubital vein. These dynamic images were processed with the“Perfusion CT”software package on workstation.Cerebral blood flow(CBF),cerebral blood volume(CBV)and time to peak(TIP)enhancement within specific regions of the brain were measured.CT angiography was constructed to show carotid and intracerebral arteries,Results Abnormal perfusion changes corresponding to clinical symptoms were found in 26 cases with prolonged TTP. Other 10 cases were normal.TIP of affected side(12.04±4.05)s was significantly prolonged compared with contralateral side(9.89±2.68)s, P＜0.01.The differences of the CBF and CBV were not statistically sig- nificant between affected side and contralateral side.CTA demonstrated stenosis or occlusion of middle cerebral artery or internal carotid artery in 26 cases with prolonged TTP.Conclusion Plain CT can exclude other in- tracerebral diseases,CTP provides hemodynamie information and CTA demonstrates presence or not of artery stenosis or occlusion.The combination of these three examinations can give information for diagnosis of TIA.