Expression and significance of Notch1 and PTEN in cervical carcinoma

Objective: To determine the expression of Notch1 and PTEN in the normal cervical tissue, CIN and cervical carcinoma and discuss the clinical significance of both in cervical cancer. Methods: The expression of Notch1 and PTEN in 50 cases of cervical carcinoma, 31 cases of CIN and 20 cases of normal endometrial tissue was detected by immunohistochemistry S-P. Results: T Notch1 and PTEN expression located in the cytoplasm and nucleus. The expression rate of Notch1in cervical cancer was 84.00%(42/50), which was obviously higher than that of the both in CIN group and normal cervical tissue(P0.05). The positive expression rate of PTEN in cervical cancer was 32.00%(16/50), which was markedly lower than that in the CIN group and normal cervical tissue expression rate(P0.05). Both of them were associated with lymph node metastasis and clinical staging and pathologic staging(P0.05). In cervical cancer tissues, the expression of Notch1 was negatively correlated with that of PTEN(P0.05). Conclusion: The expression of Notch1 and PTEN may be related with cervical cancer occurrence and development. Both of them can be used as the indexes for prognosis of cervical cancer.