Clinical Research of Traditional Chinese Medicine Combined Western Medicine in Treating 47 Cases with Lupus Nephritis

Objective: To discuss the curative efficacy and the mechanism of Langchuangshen number I decoction combined hormone and immune inhibitor in treating lupus nephritis( LN). Method: Ninety-four patients with LN were randomly divided into the western medicine group( 47 cases) and the combination group( 47cases). Patients in the western medicine group received methyl prednisolone tablets and cyclophosphamide injection. Based on the treatment of western medicine group,patients in the combination group added orally Langchuangshen number I decoction. The patients in both two groups received 6-month treatment. The systemic lupus erythematosus disease activity score( SLEDAI) at the second,fourth and sixth months after treatment were recorded. The 24-h urine protein quantitation,blood urea nitrogen( BUN) and serum creatinine( SCr) were tested before and after treatment. Besides,the levels of immunoglobulin G( Ig G),complement C3,complement C4,and the levels of resistance of double-stranded DNA( ds-DNA),plasma fibrinogen( FIB),D-dimer( D-D) were detected. Result: The clinical effect of proteinuria in the combination group was superior to that in western medicine group( P 0. 05). Score of SLEDAI in the combination group was less than that in western medicine group at the fourth and sixth months after treatment( P 0. 01). The amount of 24-h urine protein in the combination group was less than that in western medicine group after treatment( P 0. 01). The number of completely relieve cases in the combination group was more than that in western medicine group during six months.But there was no statistically significant difference between two groups. The average alleviate time in the combination group was shorter than that in western medicine group( P 0. 05). Levels of Ig G,ds-DNA,FIB and D-D in the combination group was inferior to that in western medicine group( P 0. 01). Besides,complement C3 and complement C4 levels in the combination group were higher than those in western medicine group( P 0. 05,P 0. 01). Conclusion: Langchuangshen number I decoction combined hormone and immune inhibitor coud control the disease activity in LN patients,improve blood high condensation state,protect renal function,reduce urinary protein and cut down the disease course. The curative effect of traditional Chiese medicine combined western medicine treatment is superior to western medicine treatment alone in treating LN.