Values of serum PCT and IL-6 levels for diagnosis of children with sepsis

Objective:To explore the values of serum procalcitonin(PCT) and interleukin-6(IL-6) levels for diagnosis of children with sepsis. Methods:LU-Mltest semi-automatic quantitative method and ELISA were used to detect the contents of serum PCT and IL-6,and APACHE Ⅱ scores in 30 children without sepsis(control group) and 60 children with sepsis(sepsis group) before and after effective treatment.Meanwhile,the changes of temperature and WBC count after treatment in the two groups were compared. Results:Before treatment,the levels of serum PCT and IL-6 in sepsis group were statistically significantly higher than those in control group(P0.05),but there was no statistically significant difference in APACHE Ⅱ score between the two groups(P0.05).After treatment,the change of temperature in sepsis group was statistically significantly larger than that in control group(P0.05),but there was no statistically significant difference in WBC count between the two groups(P0.05).The levels of PCT and IL-6 decreased gradually with the progress of treatment(P0.05). Conclusion:Detecting the contents of PCT and IL-6 has a certain value for early diagnosis and evaluation of therapeutic effect in children with sepsis.