Clinical significance of the surum PCT in assessing the severity and prognosis of the patients with sepsis:Analysis of 46 cases

Objective To evaluate the significance of serum procalcitonin(PCT)for estimation of severity and prognosis in patients with sepsis.Methods A total of 46 patients with sepsis were divided into three groups according to clinical severity:early sepsis group,sever sepsis group and septic shock group.To study the difference of serum PCT,CRP,WBC and APACHEⅡscores in all groups and explore the prognostic significance of the biological markers,and correlation was analyzed between PCT and APACHEⅡscores.Meanwhile,all patients were divided into three groups depending on different levels of serum PCT:5 ng/mL group,5.0-10.0 ng/mL group,≥10.0 ng/mL group.The mortality,the length of using antibiotics and hospital stay were analyzed.At the same time,the samples were performed the blood culture.Results The levels of PCT,CRP,WBC and APACHEⅡscores in septic shock were significantly higher than the severe sepsis group and the early sepsis group,compared the difference was significant(P0.05).The levels of PCT,CRP and APACHEⅡ scores were significantly different between early sepsis group and severe sepsis group(P0.05),however,the level of WBC was not(P0.05),and significant positive correlation between PCT and APACHEⅡ(r=0.68,P0.05)was found.With increasing PCT levels,the morbidity,the length of using antibiotics and hospital stay increased(P0.05),and the positive rate of the blood culture also improved.Conclusion Detecting serum PCT can be useful for assessment of severity and prognosis in patients with sepsis.