Changes of plasma CRP,TNF-a and IL-6 levels in patients with acute cerebral infarction

Objective To explore the relationship between CRP, TNF-a and IL-6 levels in the serum and the severity of the disease in patients with acute cerebral infarction (ACI). Methods Thirty cases of ACI patients and 30 cases of normal individuals were compared. The levels of CRP ,TNF-a and IL-6 in blood samples collected from the ACI patients were analyzed at the first, second and third day after onset. The relationship between the size of the infarct focus and CNFDS was studied. Results The levels of CRP, TNF-a and IL-6 in ACI patients were higher than the control group ( P0.01); CRP, TNF-a and IL-6 levels in severe group were higher than that in light and middle groups ( P0.01). The variation of CRP, TNF-a and IL-6 levels had positive correlation with CNFDS(r=0.65,0.59,0.70, P0.01). Conclusion CRP, TNF-a and IL-6 levels in serum have significant correlation with the development of ACI and its extent of severity;CRP, TNF-a and IL-6 levels in serum sample can be sensitive indexes to judge the severity of ACI.