Study of the change of serum S100β protein and CRP content in patients with acute cerebral infarction

Objective To investigate the change and its mechanism of serum S100β protein and C-reactive protein (CRP) content in patients with acute cerebral infarction(ACI).Methods The content of serum S100β and CRP in 54 patients with ACI and 21 normal control were measured. The changes of S100β and CRP were compared with patients of different pathogenetic condition and infarction sige. The correlation analysis between S100β and CRP was also made.Results The level of serum S100β and CRP in patients with ACI increased significantly compared with control group (all P0.05). The level of serum S100β and CRP increased with the score of neurofunction detection and infarction area.The level of serum S100β has positive correlation with the level of CRP.Conclusions The S100β protein can be one of the index to predict the neurofunction of ACI, as well as CRP protein do. There is the more significance if two factors combine with each other.