An Observation on Curative Effects of Compound Glycyrrhizin in the Treatment of Chronic Type B Hepatitis with Hepatic Fibrosis

OBJECTIVE:To observe on the curative effect of compound glycyrrhizin in the treatment of chronic hepatitis B with hepatic fibrosis.METHODS:146cases of chronic hepatitis B with hepatic fibrosis were administered by i.v.drop daily for4weeks with compound glycyrrhizin injection40ml～100ml,into which5%glucose injection(250ml)was added,then a sequential therapy was adopted in which all the patients were treated with50mg oral compound glycyrrhizin tablets3times per day for3months.RESULTS:The total effective rates after4weeks of first stage treatment and the sequential therapy were67.12%and81.51%(P0.05)respectively.There were significant differences in the symptoms and signs,hepatic function and hepatic fibrosis indexes after treatment compared with pre-treatment(P0.05or P0.01).CONCLUSION:Compound glycyrrhizin can effectively improve the hepatic function and resist liver fibrosis;and its curative effect is lasting and stable.