Compound Glycyrrhizin for Chronic Hepatitis B Complicating Severe Jaundice and Hepatic Fibrosis: Observation of Clinical Efficacy

OBJECTIVE:To observe the therapeutic effect of compound glycyrrhizin on chronic hepatitis B complicating severe jaundice.METHODS:A total of 95 patients with chronic hepatitis B complicating severe jaundice and were randomly assigned to receive conventional therapy plus compound glycyrrhizin(47 cases) or conventional therapy alone(48 cases).Course of treatment for both groups was 6wk. RESULTS: After treatment for 6 weeks,serum TBiL,ALT,AST,and GGT levels in the treatment group were significantly lower than in the control group(P0.05).Serum hepatic fibrosis markers including HA(hyaluronic acid),type Ⅲ procollagen,LN(laminin) and type Ⅳ collagen in the trial group were all significantly lower than in the control group(P0.05).CONCLUSION:Compound glycyrrhizin shows satisfactory efficacy for patients with chronic hepatitis B complicating severe jaundice and in improving hepatic function,subsiding jaundice,lowering hepatic fibrosis indexes,etc.