Distribution of blood culture pathogens and drug resistance

OBJECTIVE To investigate the distribution and drug resistance of pathogenic bacteria in blood culture and provide basis for clinical treatment.METHODS A total of 3462 blood samples were cultured by BacT/Alert 3D automated blood culture system,the pathogenic bacteria were identified by VITEK32 system and K-B method was used for the antibiotics susceptibility testing.RESULTS There were 467 strains of pathogens isolated from 3462 blood samples with the detection rate of 13.49%;coagulase-negative Staphylococci was the most common species,accounting for 1 22.91%(107 strains),followed by 88 strains of Escherichia coli(18.84%)and 70 strains of Klebsiella pneumoniae(14.99%);the results of drug susceptibility testing showed that gram-negative bacteria were most sensitive to imipenem,the drug resistance rates of E.coli,K.pneumonia and Salmonella were 0%,the drug resistance rates to amikacin,cefoperazone/sulbactam,and piperacillin/tazobactam ranged from 10.00% to 25.00%,the drug resistance rates to compound sulfamethoxazole were beyond 60.00%;gram-positive bacteria were most sensitive to teicoplanin,linezolid and vancomycin,the drug resistance rates of the three main species were all 0%,the drug resistance rates of coagulase-negative Staphylococci and Staphylococcus aureus to rifampicin varied from 5.00% to 10.00%,the drug resistance rates to levofloxacin and amikacin ranged from 20.00% to 30.00%,the resistance rates to penicillin were over 85.00%;Enterococci were highly resistant to antibiotics.CONCLUSION It is necessary to reasonably use antibiotics in accordance with the drug susceptibility testing of blood culture so as to reduce the drug resistant strains.