Analysis on Monitoring and Measuring Data of Plasma Concentration of Antiepileptic Drugs of 432 Cases in Our Hospital

OBJECTIVE:To analyze the monitoring and measuring data of plasma concentration of antiepileptic drugs in order to provide reference for rational use of drug in the clinic. METHODS:Access database of antiepileptic drugs was established to analyze the monitoring and measuring data of 4 kinds of antiepileptic drugs from Jan. 2001 to Jun. 2009 statistically. RESULTS:The case number of plasma concentration monitoring of antiepileptic drugs increased year by year. A total of 432 cases were involved. 48.6% of cases were in the effective plasma concentration range. Effective rates were 91.3% for carbamazepine,77.8% for phenobarbital,62.5% for sodium phenytoin and 88.2% for sodium valproic acid when plasma concentration was in the normal range. 22.2% of cases were children(aged from 0 to 10)and the old(60 years old). 43 cases of antiepileptic drugs combination accounted for 10% and the therapeutic plasma concentration of 27 cases deviated from normal range(62.8%). CONCLUSION:Results of plasma concentration monitoring provide an important basis for clinical drug use. Monitoring data and other clinical index can promote rational use of antiepileptic drugs.