Antiepileptic drug serum concentration analysis: Retrospective study of 357 children's cases

Objective:The results of serum concentration monitoring of 4 antiepileptic drugs with 357 measurements in 164 epilepsy children were evaluated in order to guide clinical rational administration of these antiepileptic drugs. Methods:The serum concentration of antiepileptic drugs sodium valproate (VPA) , carbamazepine (CBZ),sodium phenytoin (PHT) and phenobarbital (PB) were monitored by HPLC. Results:The rate of serum concentrations which were in theraputic window is 47. 1% ,and which were lower and higher Than theraputic window are 45.9% and 7.0% respectively. The serum concentrations in normal range are founded in only 49. 8% of all patients by routine administration, and deviate from normal range by 76. 2% in combination with other drugs. Conclusion: Serum concentration monitor is an important basis for the treatment of children' s epilepsies with antiepileptic drugs, especially in combination with other drugs.