Analysis of serum antiepileptic drugs concentration in 216 cases

Objective To observe the clinical therapeutic effect of antiepileptic drugs(AEDs) through the therapeutic drug monitoring(TDM ),and provide rationally individualized medication.Methods Serum concentrations of antiepileptic drugs in 216 patients from February 2012 to February 2013 were measured by homogeneous enzyme-multiplied immunoassay technique(EMIT).Results The total efficiency of antiepileptic drugs was 68.7%,and the ratio of poisoning patients reached to 6.5%.In patients with eombined treatment, the ratio of which blood drug concentrations of AEDs was higher or lower than normal therapy was up to 79. 5%.Conclusion When antiepileptic drugs are applied,blood drug concentrations should be monitored and the combination of multiple drugs should be avoided.