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Retrospective Analysis of Blood Concentration Monitoring for 3 Kinds of Antiepileptic Drugs in Our Hospital from 2003 to 2011

Dong Yu-bo

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Abstract

OBJECTIVE:To provide reference for rational use of antiepileptic drugs.METHODS:The results of blood concentration monitoring of 3 kinds of antiepileptic drugs(sodium valproate,carbamazepine,phenytoin sodium) in our hospital during 2003-2011 were analyzed retrospectively.RESULTS:The number of monitored cases for antiepileptic drugs had increased in our hospital year by year,with a total of 1 653 cases/times.Children patients accounted for 38.05% of all cases;more than half of drug concentrations monitored fell outside the normal concentration ranges,except for carbamazepine.CONCLUSION:Correct application of drug monitoring is of significance for the safety and effectiveness of epileptic treatment.

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What this paper is about

OBJECTIVE:To provide reference for rational use of antiepileptic drugs.METHODS:The results of blood concentration monitoring of 3 kinds of antiepileptic drugs(sodium valproate,carbamazepine,phenytoin sodium) in our hospital during 2003-2011 were analyzed retrospectively.RESULTS:The number of monitored cases for antiepileptic drugs had increased in our hospital year by year,with a total of 1 653 cases/times.Children patients accounted for 38.05% of all cases;more than half of drug concentrations monitored fell outside the normal concentration ranges,except for carbamazepine.CONCLUSION:Correct application of drug monitoring is of significance for the safety and effectiveness of epileptic treatment.

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Available abstract

OBJECTIVE:To provide reference for rational use of antiepileptic drugs.METHODS:The results of blood concentration monitoring of 3 kinds of antiepileptic drugs(sodium valproate,carbamazepine,phenytoin sodium) in our hospital during 2003-2011 were analyzed retrospectively.RESULTS:The number of monitored cases for antiepileptic drugs had increased in our hospital year by year,with a total of 1 653 cases/times.Children patients accounted for 38.05% of all cases;more than half of drug concentrations monitored fell outside the normal concentration ranges,except for carbamazepine.CONCLUSION:Correct application of drug monitoring is of significance for the safety and effectiveness of epileptic treatment.

Key concepts: Carbamazepine, Phenytoin, Medicine, Antiepileptic drug, Therapeutic drug monitoring, Drug, Blood concentration, Epilepsy

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