Expression of Caveolin-1,P63 and CK34βE12 in prostate cancer and its clinical significance

Objective To investigate the expression of Caveolin-1,P63 and CK34βE12 protein expression in prostate lesions and its clinical significance.Methods Immunohistochemical staining of Caveolin-1,P63 and CK34βE12 in 59 cases of prostate cancer were performed by using En Vision among with 15 cases were high grade prostatic intraepithelial neoplasia(HGPIN),11 were low grade prostatic intraepithelial neoplasia(LGPIN),7 were atypical adenomatous hyperplasia(AAH),10 were basal cell hyperplasia(BCH) and 69 were benign prostate hyperplasia(BPH).Results The positivity expression rate of Caveolin-1 in prostate cancer,HGPIN,LGPIN,AAH,BCH and BPH was 69.49%,40.00%,45.45%,28.57,30.00,8.70% respectively,the positivity expression rate of P63 was 8.47%,86.67%,90.91%,85.71%,90.00%,97.10% respectively,the positivity expression rate of CK34βE12 was 8.47%,93.33%,90.91%,100%,90.00%,95.65% respectively.The expression of Caveolin-1,P63,CK34βE12 antigen in prostate cancer and BPH specimens was significantly different(P0.05).The expression and its strength of Caveolin-1 was related to the prostate cancer Gleason score and clinical stage(P0.05).Conclusion The expression of Caveolin-1 may relate to the malignant development,invasion and metastasis in prostate cancer.Combined detection of the expression of Caveolin-1,P63,and CK34βE12 can be helpful for the early accurate diagnoses of prostate cancer and the malignancy and prognosis of prostate cancer.