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2008•Journal of Jiangsu UniversityRequires access

Value of P504S and p63 in the differential diagnosis of prostate lesions

Chuanhai Xu

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Abstract

Objective:To study the value of P504S and p63 in the differential diagnosis of prostate lesions.Methods: SP immunohistochemical staining was used to examine the expressions of P504S and p63 in105 prostate needle biopsy samples,40 prostate specimens which were excised transurethra. Results: The positive expression of P504S was observed in 20 prostate carcinomas and 12 high-grade prostatic intraepithelial neoplasias(HGPIN).No expression was observed in 20 low-grade prostatic intraepithelial neoplasias(LGPIN) and 50 benign prostatic hyperplasia specimens.The positive expression of p63 was observed in 4 HGPIN,20 LGPIN and all 50 benign prostatic hyperplasia specimens.No expression was observed in 20 prostate carcinomas. Conclusion: To detect the expressions of P504S and p63 in prostatic specimens was great useful to the diagnosis.

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Objective:To study the value of P504S and p63 in the differential diagnosis of prostate lesions.Methods: SP immunohistochemical staining was used to examine the expressions of P504S and p63 in105 prostate needle biopsy samples,40 prostate specimens which were excised transurethra. Results: The positive expression of P504S was observed in 20 prostate carcinomas and 12 high-grade prostatic intraepithelial neoplasias(HGPIN).No expression was observed in 20 low-grade prostatic intraepithelial neoplasias(LGPIN) and 50 benign prostatic hyperplasia specimens.The positive expression of p63 was observed in 4 HGPIN,20 LGPIN and all 50 benign prostatic hyperplasia specimens.No expression was observed in 20 prostate carcinomas. Conclusion: To detect the expressions of P504S and p63 in prostatic specimens was great useful to the diagnosis.

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Available abstract

Objective:To study the value of P504S and p63 in the differential diagnosis of prostate lesions.Methods: SP immunohistochemical staining was used to examine the expressions of P504S and p63 in105 prostate needle biopsy samples,40 prostate specimens which were excised transurethra. Results: The positive expression of P504S was observed in 20 prostate carcinomas and 12 high-grade prostatic intraepithelial neoplasias(HGPIN).No expression was observed in 20 low-grade prostatic intraepithelial neoplasias(LGPIN) and 50 benign prostatic hyperplasia specimens.The positive expression of p63 was observed in 4 HGPIN,20 LGPIN and all 50 benign prostatic hyperplasia specimens.No expression was observed in 20 prostate carcinomas. Conclusion: To detect the expressions of P504S and p63 in prostatic specimens was great useful to the diagnosis.

Key concepts: Prostate, Hyperplasia, Intraepithelial neoplasia, Medicine, Differential diagnosis, Immunohistochemistry, Pathology, Urology

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