Effects of epimedium on inflammatory factor of type 2 diabetic mellitus rats

Objective:To investigate the effect of epimedium on inflammatory factor in type 2 diabetic rats.Methods:Ten normal rats(normal control group)was selected from 70 diabetic rats,others was feeded by high-glucose and high-fat diet and injected streptozocin,these models with type 2 diabetic were randomly divided into diabetes mellitus(DM) model group(16 rats),epimedium group(16 rats) and metformin group(12 rats).These group were given medical for 8 weeks.We observed their blood glucose(FBG),C reaction protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6).Results:Blood glucose,CRP,TNF-α,IL-6 were significantly higher in type 2 diabetic rats groups than in normal control group(P0.01).Compared with DM model group,blood glucose,CRP,TNF-α,IL-6 were significantly decreased in epimedium group and metformin group(P0.05).There was no significant difference between epimedium group and metformin group.Conclusion:Epimedium could reduce the level of inflammatory factor and inhibit inflammatory reaction.