Significance of Using a P504s or PCNA for the Diagnosis of Prostate Needle Biopsye Lesion

Objective:Detect the expression of P504s and PCNA in human prostatic carcinoma and prostatic hyperplasia tissue and discuss the relationship with tumor differentiation and clinical stage and discuss correlations between expression of P504s and expression of PCNA.Methods:Immunohistochemistry was used to detect the expression of P504s and PCNA in 52 cases of human prostatic carcinoma tissue and 28 cases of benign prostatic hyperplasia tissue.Results:(1)PCNA protein strongly expression in prostatic carcinoma was higher than the level in the benign prostatic hyperplasia tissue,the expression of PCNA protein in two groups shows great significant difference(P0.01),and the strongly positive expression of PCNA protein in prostatic carcinoma has negatively correlation with degree of tumor differentiation and has correlation with positive correlation with clinical stage(P0.05).(2)P504s protein positive expression in prostatic carcinoma was higher than the level in the benign prostatic hyperplasia tissue,the expression of P504s protein in two groups shows great significant difference(P0.01),but the positive expression of PCNA protein in prostatic carcinoma has no correlation with degree of tumor differentiation clinical stage(P0.05).(3)Expression of PCNA protein and P504s protein in the benign prostatic hyperplasia tissue has no correlation,but PCNA protein expression and P504s protein expression in prostatic carcinoma has positive correlation.Conclusion:P504s is a sensitive and specific prostate cancer marker.Combined detection of P504s and PCNA can greatly improve the diagnosis of prostatic cancer.